Available Dosage Strengths
5% / 1% / 0.1% / 2%
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Facial Ascorbic Acid_Coenzyme Q_Hyaluronic Acid_Lipoic Acid Cream is a compounded topical cream designed to provide hydration, protection, improvement in skin tone and elasticity including improving the visible signs of aging.
Ascorbic Acid1-5
Ascorbic acid (vitamin C), an antioxidant and a water-soluble vitamin is a critical co-factor for collagen biosynthesis, carnitine and catecholamine metabolism, and systemically dietary iron absorption. Ascorbic acid is an important component to ensure that skin has a healthy integrity. Along with its antioxidant properties for the skin, it has anti-inflammatory activity, acts as a depigmenting agent, and helps in the development of collagen. Ascorbic acid deficiency causes skin aging. Thus, the external supplementation of ascorbic acid is one of the attractive strategies for skin antiaging
Ascorbic acid is not made in the body and needs to be obtained through diet or through supplements. Good sources of ascorbic acid include citrus fruits, berries, tomatoes, potatoes and green leafy vegetables.
Coenzyme Q10 (CoQ10)6-8
Coenzyme Q10 (CoQ10), a lipophilic molecule found in the body has a primary role in cellular energy metabolism through the mitochondrial electron transport chain. It also functions as an antioxidant to decrease free radicals. This neutralization of free radicals and activity in the mitochondrial transport chain system helps to decrease signs of skin aging and to help regenerate skin elasticity involved in skin aging. The level of CoQ10 decreases as you age providing less protective effects from radical oxygen species.
The combination of tretinoin and CoQ10 facilitate skin turnover and increases the protective antioxidant effects that improve skin integrity.
Hyaluronic Acid 9,10
Hyaluronic Acid, a glycosaminoglycan, has an important role for the skin. It helps maintain hydration, elasticity, and skin integrity. It also has a role in wound healing. As people age, the production of hyaluronic acid decreases, leading to drier and less elastic skin.
Lipoic Acid 11,12
Lipoic acid, known as alpha lipoic acid, may function as an antioxidant and anti-inflammatory for the skin. It is thought to reduce the effects of skin aging or skin that has gone through photodamage.
Ascorbic Acid1-5
Ascorbic acid functions in the aqueous compartments of the cell. As an antioxidant, ascorbic acid neutralizes free radicals by donating electrons to prevent oxidative stress. Reactive oxygen species are formed when skin is exposed to ultraviolet light forming superoxide ions, peroxide and singlet oxygen species. Ascorbic acid facilitates collagen development. It plays an important role in the maturation of collagen. It is a critical co-factor for prolyl hydroxylase and lysl hydroxylase. The level of ascorbic acid in the skin is directly tied to the structural integrity of dermal collagen. As a depigmenting agent, ascorbic acid interacts with copper ions at the tyrosinaseactive site and inhibits action of the enzyme tyrosinase, thereby minimizing the melanin formation. Ascorbic acid interferes with NFkB activity and thus decreases the activity of a number of proinflammatory cytokines such as TNFalfa, IL1, IL6 and IL8.
CoenzymeQ106-8
CoenzymeQ10 has a critical role as a cofactor for mitochondrial enzyme pathways within cells. Impairments in mitochondrial function disrupt cellular adenosine triphosphate (ATP) production and thereby inhibit the fuel for cellular repair mechanisms and function. Reactive oxygen species accumulate, which in turn can damage mitochondria, cellular membranes, and mitochondrial DNA, accelerating skin aging in a negative feedback loop. Coenzyme Q helps to facilitate mitochondrial activity and maintain energy. CoQ10 inhibits the ability of free radicals to activate mitogen activated protein kinase pathway and the ability of collagenases to form minimizing damage to collagen. It also decreases damage caused by lipid peroxidases to li[pids, proteins and DNA.
Hyaluronic Acid9,10
Hyaluronic acid is thought to work through two mechanisms 1) as a passive structural molecule and 2) as a signaling molecule (based on its molecular size). Hyaluronic acid has hydgroscopicity and viscoelasticity properties. It is highly anionic that can attract water. This attraction of water provides the ability of the skin to create volume and provide structural support. The signaling mechanism may be facilitated by its anti-inflammatory properties through its effects on cell migration and cell division.
Lipoic Acid11,12
There are two forms of alpha-lipoic acid. Oxidized lipoic acid and reduced dihydrolipoic acid both act as scavengers of reactive oxidized species. Dihydrolipoic is neutralizes free radicals. It also regenerates vitamins C and E and increases glutathione synthesis.
Common 1-12
Contraindications: 1-12
Precautions: 1-12
Store at 20°C to 25°C (68°F to 77°F) in a dry place, away from heat and light. Keep out of reach of children.
This information is for educational purposes only. This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.
This information may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.
