Available Dosage Strengths
5% / 1% / 0.6% / 0.01%
Want to Prescribe?
Facial – Ascorbic Acid_CoQ10_Estriol_Tretinoin Cream is a compounded topical cream designed to decrease visible signs of aging including fine lines, dullness, improve skin tone and elasticity, and address photoaging and pigmentation concerns.
Ascorbic Acid1-5
Ascorbic acid (vitamin C), an antioxidant and a water-soluble vitamin is a critical co-factor for collagen biosynthesis, carnitine and catecholamine metabolism, and systemically dietary iron absorption. Ascorbic acid is an important component to ensure that skin has a healthy integrity. Along with its antioxidant properties for the skin, it has anti-inflammatory activity, acts as a depigmenting agent, and helps in the development of collagen. Ascorbic acid deficiency causes skin aging. Thus, the external supplementation of ascorbic acid is one of the attractive strategies for skin antiaging
Ascorbic acid is not made in the body and needs to be obtained through diet or through supplements. Good sources of ascorbic acid include citrus fruits, berries, tomatoes, potatoes and green leafy vegetables.
Coenzyme Q10 (CoQ10)6-8
Coenzyme Q10 (CoQ10), a lipophilic molecule found in the body has a primary role in cellular energy metabolism through the mitochondrial electron transport chain. It also functions as an antioxidant to decrease free radicals. This neutralization of free radicals and activity in the mitochondrial transport chain system can help to decrease signs of skin aging and to help regenerate skin elasticity involved in skin aging. The level of CoQ10 decreases as you age providing less protective effects from radical oxygen species.
The combination of tretinoin and CoQ10 facilitate skin turnover and increases the protective antioxidant effects that improves skin integrity.
Estriol9-13
Micronized estriol is a bioidentical form of estriol (E3)—one of the three naturally occurring estrogens in women (alongside estradiol and estrone). Estriol is the weakest estrogen, with a much lower receptor binding affinity and duration of action than estradiol (E2). Though the weakest estrogen, estriol shows potential for skin-rejuvenating properties such as restoring dermal thickness and elasticity. Estriol is most commonly used along with estradiol in postmenopausal women with estrogen-deficiency. Estriol is most commonly prepared in a transdermal cream, allowing for incremental dosing adjustments.
Tretinoin14,15
Tretinoin, a naturally occurring derivative of vitamin A, is also called all-trans-retinoic acid. Retinoids may facilitate regulation of cell reproduction, cell proliferation and differentiation. Tretinoin is thought to facilitate skin cell turnover to improve skin texture and tone. It is used for the treatment of acne vulgaris and for photoaging including facial wrinkles, skin roughness and hyperpigmentation. For hyperpigmentation disorders, tretinoin amy prevent the transcription of the enzyme tyrosinase which minimizes melanogenesis.
Ascorbic Acid1-5
Ascorbic acid functions in the aqueous compartments of the cell. As an antioxidant, ascorbic acid neutralizes free radicals by donating electrons to prevent oxidative stress. Reactive oxygen species are formed when skin is exposed to ultraviolet light forming superoxide ions, peroxide and singlet oxygen species. Ascorbic acid facilitates collagen development. It plays an important role in the maturation of collagen. It is a critical co-factor for prolyl hydroxylase and lysl hydroxylase. The level of ascorbic acid in the skin is directly tied to the structural integrity of dermal collagen. As a depigmenting agent, ascorbic acid interacts with copper ions at the tyrosinase‑active site and inhibits action of the enzyme tyrosinase, thereby minimizing the melanin formation. Ascorbic acid interferes with NFkB activity and thus decreases the activity of a number of pro‑inflammatory cytokines such as TNF‑alfa, IL1, IL6 and IL8.
CoenzymeQ106-8
CoenzymeQ10 has a critical role as a cofactor for mitochondrial enzyme pathways within cells. Impairments in mitochondrial function disrupt cellular adenosine triphosphate (ATP) production and thereby inhibit the fuel for cellular repair mechanisms and function. Reactive oxygen species accumulate, which in turn can damage mitochondria, cellular membranes, and mitochondrial DNA, accelerating skin aging in a negative feedback loop. Coenzyme Q helps to facilitate mitochondrial activity and maintain energy. CoQ10 inhibits the ability of free radicals to activate mitogen activated protein kinase pathway and the ability of collagenases to form minimizing damage to collagen. It also decreases damage caused by lipid peroxidases to li[pids, proteins and DNA.
Estriol9-13
Estriol acts by binding to estrogen receptors alpha (ERα) and beta (ERβ) in estrogen-responsive tissues, particularly the vaginal epithelium, bladder, urethra, and pelvic floor musculature.
Mechanisms and Effects:
– Can help restore vaginal epithelial thickness and improves cell maturation index
– Can improve blood flow, elasticity, and lubrication of vaginal tissues
– Locally can improve thickening of dermal-epidermal junction, potentially improving skin firmness
– May exert cytoprotective and anti-inflammatory effects on urogenital tissues
Tretinoin14,15
Tretinoin binds to retinoic acid receptors (RARs) alpha, beta, and gamma along with retinoid X receptors (RXRs) to block inflammatory mediators. In addition, during the binding to the retinoid acid receptor, the production of procollagen increases to augment collagen type I and III formations.
Common 1-15
Contraindications: 1-15
Precautions: 1-15
Use caution in:
Store at 20°C to 25°C (68°F to 77°F) in a dry place, away from heat and light. Keep out of reach of children.
This sheet is a summary. It may not cover all possible drug information about this product. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A Wells Pharmacy Network pharmacist will be happy to answer any questions. For consultation, please call 1-800-622-4510.
